Clinical, biochemical, endoscopic and histopathological evaluation of biological treatment in ulcerative colitis / Evaluación clínica, bioquímica, endoscópica e histopatológica del tratamiento biológico de colitis ulcerativa

Introducción: El tratamiento biológico es una alternativa para manejar la colitis ulcerativa en pacientes refractarios al tratamiento convencional. Objetivo: Evaluar el tratamiento biológico en pacientes con colitis ulcerativa refractarios al tratamiento convencional en un hospital de 3er nivel de atención. Métodos: Estudio descriptivo, retrospectivo, longitudinal en pacientes con colitis ulcerativa refractarios al tratamiento convencional y que recibieron tratamiento biológico. Las cortes se evaluaron en tres momentos: estado basal (sin terapia biológica), a los seis y doce meses de inicio del tratamiento biológico. Se utilizó estadística descriptiva para la caracterización de la población en general, posteriormente los tres puntos de corte se describieron con sus respectivas variables. Resultados: Se incluyeron 18 pacientes con edad media de 41,2 años. Las evaluaciones, en un estado basal, a los seis y 12 meses; demostraron presencia de sangre en las evacuaciones y dolor abdominal en 94,4%, 22,2% y 11,1% respectivamente, concentración de hemoglobina >10,5 g/dl en 50%, 83,3% y 88,9%; concentración sérica de albúmina >3,2 g/dl en 72,2%, 83,3% y 88,9% y escala visual endoscópica de Mayo 38,9%, 33,3% y 16,7% presentaron Mayo 2 y 61,1%, 16,7% y 1,7% Mayo 3. La actividad histológica en la evaluación basal llego hasta un nivel severo (11,1%), mientras que en evaluaciones a seis y 12 meses llegaron hasta moderada en un 55,6% y 27,8% respectivamente. Conclusiones: La terapia biológica en pacientes con colitis ulcerativa refractaria demostró mejoría en manifestaciones clínicas, bioquímicas, endoscópicas e histológicas. No se registró remisión profunda de la enfermedad, ni reacciones adversas al tratamiento.

Background: Biological treatment is currently used as an alternative for the treatment of ulcerative colitis in patient's refractory to conventional treatment. Objective: To evaluate biological treatment in patients with ulcerative colitis refractory to conventional treatment in a 3rd level care Hospital. Methods: A descriptive, retrospective, longitudinal study was carried out in patients with UC who were refractory to conventional treatment and who received biological treatment. The variables were evaluated in 3 moments: basal state (without biological treatment), at six and twelve months from the start of biological treatment. Descriptive statistics were used to characterize general population, later the 3 states mentioned above were described with their respective variables. Results: Eighteen patients with a mean age of 41.2 years were included. Evaluations at baseline and at 6 and 12 months showed: presence of blood in stools and abdominal pain in 94.4%%, 22.2% and 11.1% respectively; hemoglobin concentration >10.5 g/dl in 50%, 83.3% and 88.9%; serum albumin concentration >3.2 g/dl in 72.2%, 83.3% and 88.9%; the visual Mayo endoscopic scale 38.9%, 33.3% and 16.7% presented Mayo 2 and 61.1%, 16.7% and 1.7% Mayo 3. The histological activity in the baseline evaluation reached a severe level (11.1%), while in evaluations at 6 and 12 months they reached moderate in 55.6% and 27.8% respectively. Conclusions: Biological therapy as a treatment in patients with ulcerative colitis showed improvement in clinical, biochemical, endoscopic and histological manifestations, so far none with deep remission of the disease, no adverse reactions to treatment have been presented.

Epidemiology of inflammatory bowel disease in Mexico and Colombia: Analysis of health databases, mathematical modelling and a case-series study.

BACKGROUND AND AIMS: Ulcerative Colitis (UC) and Crohn's Disease (CD) have a major impact on quality of life and medical costs. The aim of the study was to estimate the prevalence, incidence and clinical phenotypes of Inflammatory Bowel Disease (IBD) cases in Mexico and Colombia. METHODS: We analyzed official administrative and health databases, used mathematical modelling to estimate the incidence and complete prevalence, and performed a case-series of IBD patients at a referral center both in Mexico and Colombia. RESULTS: The age-adjusted complete prevalence of UC per 100,000 inhabitants for 2015/2016 ranged from 15.65 to 71.19 in Mexico and from 27.40 to 69.97 in Colombia depending on the model considered. The prevalence of CD per 100,000 inhabitants in Mexico ranged from 15.45 to 18.08 and from 16.75 to 18.43 in Colombia. In Mexico, the age-adjusted incidence of UC per 100,000 inhabitants per year ranged from 0.90 to 2.30, and from 0.55 to 2.33 in Colombia. The incidence for CD in Mexico ranged from 0.35 to 0.66 whereas in Colombia, the age-adjusted incidence of CD ranged from 0.30 to 0.57. The case-series included 200 IBD patients from Mexico and 204 patients from Colombia. The UC/CD prevalence ratio in Mexico and Colombia was 1.50:1 and 4.5:1 respectively. In Mexico, the female/male prevalence ratio for UC was 1.50:1 and 1.28:1 for CD, while in Colombia this ratio was 0.68:1 for UC and 0.8:1 for CD. In Mexico the relapse rate for UC was 63.3% and 72.5% for CD, while those rates in Colombia were 58.2% for UC and 58.3% for CD. CONCLUSIONS: The estimated burden of disease of IBD in Mexico and Colombia is not negligible. Although these findings need to be confirmed by population-based studies, they are useful for decision-makers, practitioners and patients with this condition.

[Prevalencia y factores de riesgo para lesiones premalignas en pacientes menores de 55 años sometidos a colonoscopia en un hospital de tercer nivel]. / Prevalence and risk factors for premalignant lesions in patients younger than 55 years old founded on colonoscopy on a tertiary center.

ANTECEDENTES: El cáncer colorrectal es causa importante de mortalidad y la colonoscopia es efectiva para reducir su incidencia y mejorar la supervivencia con la resección de las lesiones precursoras. OBJETIVO: Determinar la prevalencia, las características y la histología de las lesiones en pacientes < 55 años en un hospital de tercer nivel. MÉTODO: Se realizó un estudio retrospectivo y observacional de enero de 2010 a diciembre de 2014 en el Hospital de Especialidades del Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, con el reporte de 555 colonoscopias y los datos clínicos de las historias hospitalarias de los pacientes incluidos en el estudio. RESULTADOS: Los hallazgos fueron lesiones premalignas en el 40% de los pacientes, con pólipos en 98 casos y con un tamaño de 5.2 mm; de ellos, el 54% se localizaron en el colon, el 24% en el sigmoides, el 27% en el recto y el 1% en el ano. En los reportes se observó una prevalencia del 63% de pólipos neoplásicos (riesgo relativo [RR]: 2.3; intervalo de confianza del 95% [IC 95%]: 1.5-3.7) en pacientes con antecedente de tabaquismo, y del 42% (RR: 1.8; IC 95%: 1.2-2.6) con antecedente de consumo de alcohol. CONCLUSIONES: La prevalencia de lesiones premalignas es similar para los menores de 55 años. Esto indica la importancia del diagnóstico oportuno y de evitar la progresión. Sería conveniente extender el seguimiento a hospitales de segundo nivel en pacientes con factores de riesgo para ampliar lo reportado y contribuir a mejorar los resultados en la sanidad pública. BACKGROUND: Colorectal cancer is an important cause of mortality, colonoscopy is effective to reduce its incidence and improve survival with the resection of premalignant lesions. OBJECTIVE: To determine the prevalence, characteristics and histology of lesions in patients younger than 55 years of age in a tertiary hospital. METHOD: This is a retrospective observational study, we colected data at the Hospital de Especialidades del Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, with the report of 555 colonoscopies, and clinical data from the hospital archives of medic histories of selected patients. RESULTS: Premalignant lesions were found on 40% of the patients. The findings were polyps in 98 cases with a size of 5.2 mm; 54% were located in the colon, 24% in the sigmoid, 27% in the rectum and 1% in the anus. A prevalence of 63% of neoplastic polyps was observed (RR: 2.3; 95% CI: 1.5-3.7) in smokers; and 42% (RR: 1.8; 95% CI: 1.2-2.6) in patients with alcohol consumption. CONCLUSIONS: The prevalence for premalignant lesions is similar for patients under 55 years of age. This highlights the importance of early diagnosis and avoiding progression. It would be convenient to extend the follow-up to second-level hospitals in patients with risk factors to contribute to improvement of public health system outcomes.

[Double stapler technique in colorectal surgery]. / Doble engrapado en cirugía colorrectal.

BACKGROUND: Colorectal surgery has evolved significantly during the last 35 years. The circular stapler and the double stapler techniques have favored the development of very low rectal anastomoses with reduction in anastomotic leakage. The objective of this study is to evaluate the functional results and complication rate of this surgical technique in the Department of Colorectal Surgery at the Hospital de Especialidades, Centro Medico Nacional Siglo XXI and at the Hospital Angeles del Pedregal, both located in Mexico City. METHODS: Clinical records of patients who underwent surgery from May 1995 to December 2005 using the double stapler technique and performed by the authors were reviewed. RESULTS: The study included 142 patients, 55 of whom had rectosigmoid cancer resections. Average age was 60.1 years (male predominance 52.05%). The circular stapler most frequently used was CDH 33 (Johnson & Johnson). Average distance between the anal margin and the anastomoses for extended low anastomoses was 3.21 cm (low 7.8 cm and high 13.7 cm), and the rate of anastomoses leak was 3.52%. CONCLUSIONS: Double stapler technique used to treat rectosigmoid pathology is safe, secure and assures intestinal continuity in low anterior as well as extended low anterior resections with primary anastomoses. In those patients with associated risk factors and low extended low anterior resection with primary anastomoses, we recommend performing a protective stoma (ileostomy).

Doble engrapado en cirugía colorrectal / Double stapler technique in colorectal surgery

BACKGROUND: Colorectal surgery has evolved significantly during the last 35 years. The circular stapler and the double stapler techniques have favored the development of very low rectal anastomoses with reduction in anastomotic leakage. The objective of this study is to evaluate the functional results and complication rate of this surgical technique in the Department of Colorectal Surgery at the Hospital de Especialidades, Centro Medico Nacional Siglo XXI and at the Hospital Angeles del Pedregal, both located in Mexico City. METHODS: Clinical records of patients who underwent surgery from May 1995 to December 2005 using the double stapler technique and performed by the authors were reviewed. RESULTS: The study included 142 patients, 55 of whom had rectosigmoid cancer resections. Average age was 60.1 years (male predominance 52.05%). The circular stapler most frequently used was CDH 33 (Johnson & Johnson). Average distance between the anal margin and the anastomoses for extended low anastomoses was 3.21 cm (low 7.8 cm and high 13.7 cm), and the rate of anastomoses leak was 3.52%. CONCLUSIONS: Double stapler technique used to treat rectosigmoid pathology is safe, secure and assures intestinal continuity in low anterior as well as extended low anterior resections with primary anastomoses. In those patients with associated risk factors and low extended low anterior resection with primary anastomoses, we recommend performing a protective stoma (ileostomy).

[Intestinal damage by non-steroidal anti-inflammatory drugs]. / Daõ intestinal por antiinflamatorios no esteroideos.

BACKGROUND: Nonsteroidal antiinflammatory Drugs (NSAIDS) are the most widely prescribed medication in the world, with a high complication rate including gastrointestinal damage. OBJECTIVE: To present two clinical cases of intestinal damage associated to the chronic ingestion of NSAIDs. METHOD: A clinical case with inflammatory bowel disease and jejunum enteropathy and another case associated with clinical symptoms of digestive hemorrhage and endoscopic demostration of ulcers in the right colon. CONCLUSION: Patients with previous ingestion of NSAIDs presenting diarrhea, gastrointestinal bleeding, malnutrition or anemia need to discard intestinal damage.

[Anorectal tuberculosis. Case report]. / Tuberculosis anorrectal. Reporte de un caso.

OBJECTIVE: To report for the first time in Mexico a case of anorectal tuberculosis as well as the revision of world-wide literature. BACKGROUND: In recent years the tuberculosis has had a significant increase, caused mainly by the epidemic of acquired immunodeficiency syndrome. The anorectal tuberculosis is a very rare presentation, their diagnosis requires a high index of suspicion since it can be confused with an infectious disease. CASE REPORT: Female of 50 years old, with atipic annal ulcers, treated at the being like perianal Crohn disease, the treatment with mesalazina and prednisona do not improve the disease. Thorax x-ray was made. The biopsies reported tuberculosis, initiating treatment with triple antifimic scheme, with good results at one month of medical treatment. COMENT: The biopsy is the main diagnostic method specific, the medical triple or quadruple treatment is the main management and surgical treatment is reserved for anal abscess and fistula.

[Rectal diverticula. Case report]. / Divertículos rectales. Informe de un caso.

BACKGROUND: The presence of rectal diverticula is extremely rare; nevertheless, diverticular disease is considered a greater problem. We report a case of rectal diverticula in a patient with diverticular disease of the sigmoid. CLINICAL CASE: An 88-year-old male presented to the emergency room with hematochezia of several days evolution. During colonoscopy two diverticula were seen at 5 cm from the anal verge. DISCUSSION: Two theories exist to explain why rectal diverticula are rare, but other authors indicate its relationship to genetic alterations. Rectal diverticula are generally asymptomatic and surgical treatment only becomes necessary when these lesions progress to ulceration and abscess formation.